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COURSE TIME:
Thursday 5:10-7:00 pm.
COURSE LOCATION: Physics 416
INSTRUCTOR:
Richard Scalettar
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Tentative Schedule:
Thursday, April 13: Thursday, April 20: Thursday, April 27: Thursday, May 4: Thursday, May 11: Thursday, May 18: Thursday, May 25: Thursday, June 1: Thursday, June 8:
Readings:
Thursday, April 6:
Introductions.
General discussion of course.
Video (14 minutes) "A cure for no cures"
https://www.youtube.com/watch?v=W3C23m71Yws
Video (18 minutes) "Reimagining pharmaceutical Innovation"
https://www.youtube.com/watch?v=rTMqGbTNkNg
First Reading Assigned:
"History of Drug Discovery and Development" by Rick Ng.
Student presentations following up on Section A1.1 of Week One reading:
Chinese, Egyptian, Indian, Greek Medicine;
or
Section A1.2: drug
discovery in the early church and in Arabian medicine.
Select one of the paragraphs in Ng's article and
expand upon it: What sorts of drugs were discovered by different
cultures? How were they discovered and by whom? Did they work?
If yes, how? Are they still used? Etc.
Second Reading Assigned:
"The Changing Role of
Chemistry in Drug Discovery," an interview with Cathy Tralua-Stewart
(Imperial College, London),
Derek Lowe (researcher and blogger), David Leahy (CEO, Molplex),
Allan Moorman (Alta Vetta Pharmaceutical Consulting),
Alex Tropsha (University of North Carolina), and Paul Leeson
(AstraZeneka).
This will give some background to
Dr. Heather Harris'
talk in the
following week.
Discussion led by Dr. Heather Harris, researcher in pharmaceutical
industry (Pfizer).
Third Reading Assigned:
"Early Drug Discovery and the rise of pharmaceutical chemistry."
Student presentations.
Select one of the early scientists profiled in the Third Reading:
von Liebig (chloroform),
Liebreich (chloral hydrate),
von Bayer (barbituric acid),
Kekul\'e (aromatic rings),
von Mering (barbital), Etc.
Discuss what they accomplished. Was there something
interesting about their background? What led them to do research
into drugs?
Video: Why Prescription Drugs Cost So Much
https://www.youtube.com/watch?v=GHcCs4TPvYA
Be prepared to discuss: What do you think about the costs of health care
and the United States health care system in general?
What do you know about President Obama's "Affordable Health Care Act"?
Was it good/bad? What are the elements of President Trump's
planned replacement?
Presentation by
Genentech Campus Ambassadors
and discussion.
Fourth Reading Assigned:
"Drug Discovery: A Historical
Perspective", by Juergen Drews.
This is the most technical of all the readings.
Student Presentations. Select one of the technical
aspects in the Fourth Reading and explain what it really means.
For example:
What is a 'structural pathway'?
What is a 'receptor'?
What are 'disease genes'?
Etc.
Presentation by Courtney Manning, Allison Lee, Megan Tsao, and Wahib Ead
on applying to pharmacy school (much of
the information/advice will be pertinent to other graduate programs):
personal statements, extracurriculars, getting letters of
recommendation, interview preparation, and school research.
In terms of pharmacy
school specifics, she will talk about the PCAT (Pharmacy College Admission
Test), PharmCAS (Pharmacy College Admission System), and supplemental
applications.
Discussion led by
Libby Drumm, Pharm.D.,
recent Thomas Jefferson
pharmacy school graduate, and grad-intern pharmacist
at CVS.
Closing discussions. Course summary.
History of Drug Discovery and Development
Early Drug Discovery and the Rise of Pharmaceutical Chemistry
Drug Discovery: A Historical Perspective
The Changing Role of Chemistry in Drug Discovery